It is used in medical institutions and is intended for injection into the dermal layer of theskin (e.g., face, neck, hands, etc.). It can significantly boosts hydration, enhance skin elasticity of sagging skin, improve dull skin tone, and smooth away fine lines.
10mg/mL: 0.5mL, 1.0mL, 1.5mL, 2.0mL, 2.5mL, 3.0mL
10 mg/mL Hyaluronic Acid (non-crosslinked)
People with dry, dehydrated skin, or fine lines and wrinkles.
Hydrate, plump, and rejuvenate the skin by restoring natural moisture and improving elasticity.
After high-molecular-weight hyaluronic acid is injected into the dermal layer of the skin, the carboxyl groups and other polar groups in hyaluronic acid molecules can form hydrogen bonds with water to bind a large amount of moisture.
This enhances the skin's hydration capacity, increases skin volume to fill superficial wrinkles, and improves skin moisture content from the inside out under the action of aquaporins—significantly boosting the moisture content of the stratum corneum, reducing fine lines, and enhancing skin elasticity.
Meanwhile, sodium hyaluronate can also stimulate the proliferation of fibroblasts and promote the synthesis of collagen, which further enhances skin elasticity and helps restore firmness to sagging skin.
A prospective, multi-center, randomized, placebo-controlled, assessor-blinded, and superiority clinical trial design was conducted.
A total of 484 subjects were enrolled, with a 3-month follow-up period. The subjects were adults in need of temporary improvement in facial skin condition (such as dry skin and dull skin tone). The test group received injections of SKformula at week 0, 4, and 8, with each dose ranging from 3 to 6 mL.
Summary of Clinical Trial Results and Conclusions: In terms of efficacy evaluation, the proportion of patients with sustained skin improvement for 4 weeks was 92.6%, and for 3 months was 89.1%; the proportion of patients with sustained Global Aesthetic Improvement Scale (GAIS) effect for 4 weeks was 93.9%, and for 3 months was 89.5%.
No adverse events occurred.


Based on the comparison of the two sets of data, it can be concluded that the skin moisture and elasticity levels of the test group showed a steady increasing trend at weeks 4, 8, and 12 after continuous use of the SKformula product. Moreover, the degree of improvement at each time point was significantly better than that of the blank control group, indicating that the product delivers clear and sustained effects in long-term moisturizing and enhancing skin elasticity.
World Top HA Raw material
Using exceptionally pure, Kewpie Corporation non-animal Hyaluronic Acid, with strict quality control and Japanese Pharmacopoeia compliance, this formulation deeply moisturizes the skin while smoothing and refining its texture.
Long-lasting Hydration with High-Molecular-Weight HA
By utilizing high-molecular-weight sodium hyaluronate (approximately 2 million Daltons), the product ensures superior hydrating and moisture-locking performance, offering over 3 months of plumping and revitalization effects.
High Safety Profile & Pyrogen-Free
With significantly reduced levels of endotoxins and foreign proteins, plus a streamlined ingredient composition, it greatly minimizes the risk of adverse reactions and supports greater skin compatibility.
Versatile Usage
HA Mesotherapy's versatility shines as it deeply hydrates and boosts collagen, making it a perfect
partner with ingredients like vitamins, PDRN, collagen stimulators (like PDLLA) to enhance overall rejuvenation.
Injection Sites
Face
Neck
Decollete area
Backs of hands
Peri-orbital area (eye contour)
It should be injected into healthy disinfected skin with no sign of inflammation.
This implant is designed to be injected into the dermis by a licensed medical practitioner using the appropriate technique.
This treatment can be carried out manually using a 32G needle or in association with a device like mesotherapy injector.
Treatment protocol consists in 3 sessions spaced out between 4 weeks.
Optimal results lasting 3+ months.
Tailor the protocol to skin type and concerns—more products don't always mean better results. Start with a basic HA solution, then add only 1-2 targeted agents.
The typical dose is 3–6 mL per session (5 mL is common), adjusted individually for skin area, thickness, and product specifics. Always blend products proportionally based on their concentrations.
Examples of Combination Protocols:
HA + Regenerative/Collagen Booster
Lifts, firms, reduces fine lines
HA + Vitamin C + Glutathione
Antioxidant brightening
HA + PDRN/PN
Boosts metabolism, anti-inflammatory
HA + Botulinum Toxin
Reduces fine lines, pores, oil, and acne
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