What Is the Difference Between PLLA Fillers and Hyaluronic Acid Fillers?

In the world of aesthetic medicine, dermal fillers have revolutionized the way we treat signs of aging—without surgery. But not all fillers are created equal. Two of the most popular options are PLLA (poly-L-lactic acid) fillers and hyaluronic acid (HA) fillers. While they may seem similar at first glance, they work in fundamentally different ways and serve different purposes.

So, what’s the real difference between PLLA fillers and HA fillers? Let’s dive in.

What Are Hyaluronic Acid (HA) Fillers?

Hyaluronic acid is a naturally occurring sugar molecule found in your skin and connective tissues. Its main job is to retain moisture and keep the skin hydrated and plump.

Hyaluronic Acid HA filler is a gel-like substances made from synthetic HA, which mimic the body’s natural HA.

Key Features of HA Fillers

• Immediate results: You’ll see volume and smoothing effects right after treatment.

• Reversible: If needed, HA fillers can be dissolved using hyaluronidase.

• Hydration boost: Great for giving skin a fresh, dewy glow.

• Versatile use: Perfect for lips, cheeks, under eyes, smile lines, and more.

Reference: American Society for Dermatologic Surgery. “Hyaluronic Acid Fillers.” ASDS.net

What Are PLLA Fillers?

Poly-L-lactic acid (PLLA) is a biodegradable, biostimulatory filler. Unlike HA, it doesn't just fill space—it stimulates your skin to produce its own collagen over time.

PLLA dermal fillers are injected deeper into the dermis and act more like a collagen stimulator than a volumizer. Results appear gradually over several weeks or months.

Key Features of PLLA Fillers

• Stimulates collagen production

• Gradual, long-lasting results (up to 2 years)

• Ideal for deep wrinkles and volume loss

• Non-reversible (cannot be dissolved like HA)

Reference: Sadick, N. (2008). “A study to determine the efficacy of poly-L-lactic acid for facial rejuvenation.” J Drugs Dermatol, 7(3), 248–254.

PLLA vs HA: Key Differences at a Glance

Reference: Lemperle, G., et al. (2004). “Human histology and persistence of various injectable filler substances.” Aesthetic Plastic Surgery, 27, 354–366. https://doi.org/10.1007/s00266-003-3022-2

Which Filler Should You Choose?

It depends on your goals, age, and how fast you want results:

Choose HA fillers if:

• You want immediate results

• You’re new to fillers and want something reversible

• You’re treating delicate areas (like lips or tear troughs)

• You prefer lower risk and simpler maintenance

Choose PLLA fillers if:

• You're looking for long-term improvement

• You want to build natural collagen over time

• You have deep facial volume loss

• You're okay waiting weeks to see results

Reference: Gold, M. H. (2007). “Use of poly-L-lactic acid for facial rejuvenation.” Clinics in Dermatology, 26(6), 633–638.

Safety & Side Effects

Common side effects for both:

• Mild swelling

• Bruising

• Redness at injection sites

Unique considerations:

• HA fillers can be reversed, reducing risk of long-term complications.

• PLLA fillers require expert technique to avoid nodules or uneven collagen formation.

Always ensure your treatment is done by a licensed, experienced injector who understands facial anatomy and filler behavior.

Reference: American Society of Plastic Surgeons. “Dermal Fillers – Risks and Safety.” plasticsurgery.org

Both PLLA and HA fillers offer excellent results—but for different needs. If you want instant smoothing or plumping, HA fillers are a great choice. If you're seeking long-term, natural rejuvenation, PLLA fillers may be your match.

The best filler is the one tailored to your unique goals, budget, and anatomy—so consult with a certified professional to develop the perfect treatment plan.