Singderm Volast Dextran Filler

Core Ingredient: Crosslinked Dextran

Specification: 0.5mL, 0.75mL, 1.0mL, 1.25mL, 1.5mL; supplied with 27G needles

Indications: This product is applicable for injection into the middle to deep layers and subcutaneous of the facial dermal tissue to correct moderate to severe wrinkles and restore tissue volume

Injection Layer: Middle to deep layers and subcutaneous of the facial dermal tissue

Efficacy: Instant fill and long-lasting collagen stimulation

Suitable For: People who need long-term improvement of skin contours

What Is Dextran?

Dextran is a polymer of glucose molecules found in various plants and fungi, such as mushrooms, yeast, and algae. lt is a white bead-like microsphere with a porous network structure.

Dextran has excellent biocompatibility and drug-carrying capacity, making it a commonly used filling material. In addition, dextran can promote wound healing and help slow down skin aging.

Dextran, Safe Material

Dextran can be used as a plasma infusion agent and is a recognized safe substance. As a polysaccharide similar to hyaluronic acid, it has good biocompatibility and hydrophilicity. It is 100% decomposed into H2O and CO2 in the body and disappears. The decomposition time

is about 1-2 years. At the same time, its endotoxin levels are low, indicating its high biosafety.

The Development History of Dextran Fillers

Mode of Action

1. Physical Support

By injecting cross-linked dextran gel into the dermal layer or subcutaneous tissue of the skin,

it achieves immediately visible improvement effects utilizing its physical supporting properties.

The network structure of dextran gel degrades relatively slowly in the body, allowing it to maintain long-term filling effects and improve skin condition.

2. Biostimulation of Collagen Regeneration

Once dextran enters the human body, it stimulates macrophages and fibroblasts, promoting

the generation of new collagen and new blood vessels.

·The dextran is eventually enveloped by collagen, forming collagen capsules.

·The dextran itself will decompose, but the collagen capsules still have a space-filling effect

that can last for more than 3 years.

Advantage

High Safety

Natural Dextran: Singderm® Volast, a natural polysaccharide, can be completely metabolized by the human body and it can exhibit excellent biocompatibility, minimizing allergic reactions and rejections.

Soft Gel Texture

Compared to other regenerative materials, Singderm® Volast prevents embolism and nodule formation.

Self-Crosslinking Technology

This ensures no residual crosslinking agents in Singderm® Volast, guaranteeing product purity.

Natural Sculpting with Enhanced Comfort

Natural Results: Soft texture, providing a natural look and feel after filling.

Superior Support: Singderm® Volast with high elasticity (1000-1200Pa) delivers excellent support,

particularly suitable for deep layer injections and contouring. Meanwhile, it has low extrusion force (5-10N) for precise, painless injections.

Dual-Action Rejuvenation

Stimulates Collagen Regeneration:

Promotes the production of type I and type III collagen, improves skin tightness and smoothness.

In addition, the product has anti-inflammatory effects, reducing inflammation after injection.

Immediate Filling: Due to its viscoelastic properties, a small amount of injectoin can significantly

improve sunken areas of the face, providing an immediate lifting effect.

Long-Term Efficacy

While dextran degrades in 1-2 years, Singderm® Volast can induce collagen capsules sustain effects for over 3 years, ensuring durable results.

Duration

Over 3 Years

Treatment Areas

Cheeks

Nose base

Nasolabial folds

Marionette lines

Chin

Contraindications

1. The person who are allergic to any component of the product are prohibited for using.

2. It is prohibited for using in patients under 18 years.

3. It is prohibited for pregnant or lactating women.

4. It should be used with caution for those with a tendency to keloid formation or a history of hypertrophic scar.

5. Patients with atrophic skin diseases should use this product with caution.

6. Those with capillary dilation should use this product with caution.

7. People who are using anticoagulants such as heparin and aspirin should use this product with caution.

Precautions

1. Intradermal injection carries a risk of infection, consistent with general precautions for dermal injections. Therefore, local disinfection should be performed before injection, and the injection process should follow the aseptic operation regulations of surgical treatment.

2. For patients taking medications that affect platelet function, injections may cause bruising or bleeding at the injection site.

3. Prevent mixing with any other injectable implant products.

4. The total injection volume of each injection should not exceed 3 mL.

5. The medical effect and retention time are affected by the following factors: the nature of the defect itself, the degree of correction, the depth of implantation, the physicians’ injection technique, and individual physical differences